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Official Danger Model Home Page
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The new wave in immunology, the Danger Model has slain the self/nonself dragon put forth by Nobel Laureate Macfarlane Burnet.
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An understanding of the Danger Model may facilitate the development of novel and exciting therapies of autoimmune disease, infection, and cancer.
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Wife Rima Couzi and baby Jonathan relax at the Inner Harbor in Baltimore, Maryland
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The danger model begins with the theory, first put forth by Donald Forsdyke and popularized by Peter Bretscher and Mel Cohn, that lymphocytes require two signals for efficient activation. Signal one is recognition of antigen, and signal two is a "costimulatory" signal delivered by the antigen-presenting cell.
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